Fish T cells: recent advances through genomics

Developmental and Comparative Immunology
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Abstract

This brief review is intended to provide a concise overview of the current literature concerning T cells, advances in identifying distinct T cell functional subsets, and in distinguishing effector cells from memory cells. We compare and contrast a wealth of recent progress made in T cell immunology of teleost, elasmobranch, and agnathan fish, to knowledge derived from mammalian T cell studies. From genome studies, fish clearly have most components associated with T cell function and we can speculate on the presence of putative T cell subsets, and the ability to detect their differentiation to form memory cells. Some recombinant proteins for T cell associated cytokines and antibodies for T cell surface receptors have been generated that will facilitate studying the functional roles of teleost T cells during immune responses. Although there is still a long way to go, major advances have occurred in recent years for investigating T cell responses, thus phenotypic and functional characterization is on the near horizon.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Fish T cells: recent advances through genomics
Series title Developmental and Comparative Immunology
DOI 10.1016/j.dci.2011.03.004
Volume 35
Issue 12
Year Published 2011
Language English
Publisher Elsevier
Contributing office(s) Western Fisheries Research Center
Description 14 p.
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Developmental and Comparative Immunology
First page 1282
Last page 1295