Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers

Jeffrey C. Wolf; Wes A. Baumgartner; Vicki Blazer; Alvin C. Camus; Jeffrey A. Engelhardt; John W. Fournie; Salvatore Frasca Jr.; David B. Groman; Michael L. Kent; Lester H. Khoo; Jerry M. Law; Eric D. Lombardini; Christine Ruehl-Fehlert; Helmut E. Segner; Stephen A. Smith; Jan M. Spitsbergen; Klaus Weber; Marilyn J. Wolfe

doi:10.1177/0192623314540229

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers

Toxicologic Pathology

By: Jeffrey C. Wolf, Wes A. Baumgartner, Vicki Blazer, Alvin C. Camus, Jeffrey A. Engelhardt, John W. Fournie, Salvatore Frasca Jr., David B. Groman, Michael L. Kent, Lester H. Khoo, Jerry M. Law, Eric D. Lombardini, Christine Ruehl-Fehlert, Helmut E. Segner, Stephen A. Smith, Jan M. Spitsbergen, Klaus Weber, and Marilyn J. Wolfe

https://doi.org/10.1177/0192623314540229

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Abstract

Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.

Additional publication details
Publication type	Article
Publication Subtype	Journal Article
Title	Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers
Series title	Toxicologic Pathology
DOI	10.1177/0192623314540229
Volume	43
Issue	3
Year Published	2015
Language	English
Publisher	Society of Toxologic Pathology
Contributing office(s)	Leetown Science Center
Description	29 p.
First page	297
Last page	325
Online Only (Y/N)	N
Additional Online Files (Y/N)	N
Google Analytic Metrics	Metrics page