Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus

mBio
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Abstract

Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV.

Publication type Article
Publication Subtype Journal Article
Title Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus
Series title mBio
DOI 10.1128/mBio.01180-15
Volume 6
Issue 4
Year Published 2015
Language English
Publisher American Society for Microbiology
Contributing office(s) National Wildlife Health Center
Description e01180-15, 10 p.
Online Only (Y/N) N
Additional Online Files (Y/N) N
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