1. Fish liver microsomal systems have been found to catalyze the hydroxylation of aniline and acetanilide, the N-demethylation of aminopyrine and the O-dealkylation of phenacetin.
2. These systems are similar to the corresponding mammalian enzymes and they may be considered to be mixed function oxidase since they require NADPH and oxygen. An absolute requirement for oxygen, however, was difficult to demonstrate for the hepatic phenacetin cleavage system from fish.
3. Microsomal drug metabolizing systems from fish have temperature optima which are considerably lower than those of corresponding mammalian systems
Additional publication details
|Publication Subtype||Journal Article|
|Title||The oxidation of drugs by fishes|
|Series title||Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology|
|Contributing office(s)||Columbia Environmental Research Center|
|Online Only (Y/N)||N|
|Additional Online Files (Y/N)||N|