The oxidation of drugs by fishes

Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology
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Abstract

1. Fish liver microsomal systems have been found to catalyze the hydroxylation of aniline and acetanilide, the N-demethylation of aminopyrine and the O-dealkylation of phenacetin.
2. These systems are similar to the corresponding mammalian enzymes and they may be considered to be mixed function oxidase since they require NADPH and oxygen. An absolute requirement for oxygen, however, was difficult to demonstrate for the hepatic phenacetin cleavage system from fish.
3. Microsomal drug metabolizing systems from fish have temperature optima which are considerably lower than those of corresponding mammalian systems

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title The oxidation of drugs by fishes
Series title Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology
DOI 10.1016/0010-406X(68)90931-6
Volume 25
Issue 1
Year Published 1968
Language English
Publisher Elsevier
Contributing office(s) Columbia Environmental Research Center
Description 17 p.
First page 223
Last page 239
Online Only (Y/N) N
Additional Online Files (Y/N) N