Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken

Environmental Toxicology and Chemistry
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Abstract

Studies were conducted to develop methods to assess the effects of a complex mixture of polychlorinated biphenyls (PCBs) in the domestic chicken (Gallus domesticus). Treatments were administered by egg injection to compare embryonic effects of an environmentally relevant PCB congener mixture in the domestic chicken over a range of doses. Chicken eggs were injected with the PCB mixture with a profile similar to that found in avian eggs collected on the upper Hudson River, New York, USA, at doses that spanned 0 to 98 μg/g egg. Eggs were hatched in the laboratory to ascertain hatching success. In the domestic chicken, the median lethal dose was 0.3 μg/g. These data demonstrate adverse effects of an environmentally relevant PCB mixture and provide the basis for further work using in vitro and other models to characterize the potential risk to avian populations. 

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Embryonic effects of an environmentally relevant PCB mixture in the domestic chicken
Series title Environmental Toxicology and Chemistry
DOI 10.1002/etc.4218
Volume 37
Issue 10
Year Published 2018
Language English
Publisher SETAC
Contributing office(s) Columbia Environmental Research Center
Description 10 p.
First page 2513
Last page 2522