Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey

Steve Lantz; Bob Adair; Jon Amberg; Roger A. Bergstedt; Michael A. Boogaard; Ugo Bussy; Margaret F. Docker; Erin S. Dunlop; Alex Gonzalez; Terrance Hubert; Michael J. Siefkes; Paul Sullivan; Steve Whyard; Michael P. Wilkie; Bradley Young; Andrew M. Muir

doi:10.1139/cjfas-2020-0316

Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey

Canadian Journal of Fisheries and Aquatic Sciences

By: Steve Lantz, Bob Adair, Jon Amberg, Roger A. Bergstedt, Michael A. Boogaard, Ugo Bussy, Margaret F. Docker, Erin S. Dunlop, Alex Gonzalez, Terrance Hubert, Michael J. Siefkes, Paul Sullivan, Steve Whyard, Michael P. Wilkie, Bradley Young, and Andrew M. Muir

https://doi.org/10.1139/cjfas-2020-0316

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Abstract

Successful integrated management of the invasive predatory sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes of North America is owed largely to the long history of beneficial use of two lampricides: 3-trifluoromethyl-4-nitrophenol (TFM) and 2′,5-dichloro-4′-nitrosalicylanilide (niclosamide). Ensuring continued successful sea lamprey control necessitates consideration of possible next-generation lampricides to supplement or replace current lampricides. This review identifies fifteen hallmarks of success for current lampricides to be used as design criteria in a search for next-generation lampricides. A three-stage research approach is outlined. Targeted research using omics, computer modelling, and high-throughput technology to define molecular mechanisms and high probability molecular targets for sea lamprey selective toxic action is crucial to prioritizing chemical candidates. Targeted delivery or identifying synergists to existing or new lampricides can provide increased efficiency and reduced environmental impact. Ultimate development of next-generation lampricides will rely on traditional toxicity testing methodologies to ensure safety and regulatory compliance.

Additional publication details
Publication type	Article
Publication Subtype	Journal Article
Title	Next-generation lampricides: A three-stage process to develop improved control tools for invasive sea lamprey
Series title	Canadian Journal of Fisheries and Aquatic Sciences
DOI	10.1139/cjfas-2020-0316
Volume	79
Issue	4
Year Published	2022
Language	English
Publisher	Canadian Science Publishing
Contributing office(s)	Upper Midwest Environmental Sciences Center
Description	11 p.
First page	692
Last page	702
Google Analytic Metrics	Metrics page