Sex‐related differences in aging rate are associated with sex chromosome system in amphibians

Hugo Cayuela; Jean-François Lemaître; Jean-Paul Léna; Victor Ronget; Iñigo Martínez-Solano; Erin L. Muths; David Pilliod; Benedikt Schmidt; Gregorio Sánchez-Montes; Jorge Gutierrez-Rodriguez; Graham Pyke; Kurt Grossenbacher; Omar Lenzi; Jaime Bosch; Karen H. Beard; Lawrence L. Woolbright; Brad A. Lambert; David M. Green; Justin M Garwood; Robert N. Fisher; Kathleen Matthews; David Dudgeon; Anthony Lau; Jeroen Speybroeck; Rebecca Homan; Robert Jehle; Eyup Baskale; Emiliano Mori; Jan W. Arntzen; Pierre Joly; Rochelle Stiles; Michael J Lannoo; John C. Maerz; Winsor H. Lowe; Andres Valenzuela-Sanchez; Ditte Christianson; Claudio Angelini; Jean-Marc Thirion; Juha Merila; Guarino R. Colli; Mariana M. Vasconcellos; Taissa C. Boas; Isis da C. Arantes; Pauline Levionnois; Beth A. Reinke; Cristina Vieira; Gabriel A. B. Marais; Jean-Michael Gaillard; David A.W. Miller

doi:10.1111/evo.14410

Sex‐related differences in aging rate are associated with sex chromosome system in amphibians

Evolution

By: Hugo Cayuela, Jean-François Lemaître, Jean-Paul Léna, Victor Ronget, Iñigo Martínez-Solano, Erin L. Muths, David Pilliod, Benedikt Schmidt, Gregorio Sánchez-Montes, Jorge Gutierrez-Rodriguez, Graham Pyke, Kurt Grossenbacher, Omar Lenzi, Jaime Bosch, Karen H. Beard, Lawrence L. Woolbright, Brad A. Lambert, David M. Green, Justin M Garwood, Robert N. Fisher, Kathleen Matthews, David Dudgeon, Anthony Lau, Jeroen Speybroeck, Rebecca Homan, Robert Jehle, Eyup Baskale, Emiliano Mori, Jan W. Arntzen, Pierre Joly, Rochelle Stiles, Michael J Lannoo, John C. Maerz, Winsor H. Lowe, Andres Valenzuela-Sanchez, Ditte Christianson, Claudio Angelini, Jean-Marc Thirion, Juha Merila, Guarino R. Colli, Mariana M. Vasconcellos, Taissa C. Boas, Isis da C. Arantes, Pauline Levionnois, Beth A. Reinke, Cristina Vieira, Gabriel A. B. Marais, Jean-Michael Gaillard, and David A.W. Miller

https://doi.org/10.1111/evo.14410

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Abstract

Sex‐related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture–recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed that the strength and direction of sex differences in aging rates (and not lifespan) differ between XY and ZW systems. Sex‐specific variation in aging rates was moderate within each system, but aging rates tended to be consistently higher in the heterogametic sex. This led to small but detectable effects of sex chromosome system on sex differences in aging rates in our models. Although preliminary, our results suggest that exposed recessive deleterious mutations on the X/Z chromosome (the “unguarded X/Z effect”) or repeat‐rich Y/W chromosome (the “toxic Y/W effect”) could accelerate aging in the heterogametic sex in some vertebrate clades.

Additional publication details
Publication type	Article
Publication Subtype	Journal Article
Title	Sex‐related differences in aging rate are associated with sex chromosome system in amphibians
Series title	Evolution
DOI	10.1111/evo.14410
Volume	76
Issue	2
Year Published	2022
Language	English
Publisher	Oxford Academic
Contributing office(s)	Fort Collins Science Center
Description	10 p.
First page	346
Last page	356
Google Analytic Metrics	Metrics page