Earthquake risk associated with Quito, Ecuador; Cali, Colombia; and Santiago de los Caballeros, Dominican Republic is examined by generating a set of hypothetical earthquake scenarios considering seismic sources, recent seismicity, and major historical earthquakes recorded in the vicinity. In this study, particular focus is given to the development of earthquake scenarios for use in emergency planning in each city as well as stimulating discussion with respect to addressing the gaps in current understanding of built stock inventory and their vulnerability when subjected to strong shaking. Exposure and vulnerability models from the Global Earthquake Model foundation, hazard and local site information available for the cities, and the U.S. Geological Survey near‐real‐time products are utilized to estimate potential consequences for postearthquake response planning. Results showed that the historic city centers remain the most susceptible to experiencing severe damage resulting in widespread casualties. Similarly, the scenarios highlight areas susceptible to shaking induced ground failure hazards, which may pose additional challenges when responding to such earthquakes. Moderate earthquakes originating from nearby seismic sources, for example, Quito fault system for Quito or the Septentrional fault zone in the case of Santiago de Los Caballeros, could potentially be of greater consequence in terms of direct economic impact and disruption to the city when compared to very large distant subduction interface earthquakes.