Severe thunderstorm activity during August 8–11, 2010 in central and southeast Iowa resulted in major flooding from August 11–16, 2010, in the South Skunk River Basin. Rain gages at Ames and Story City recorded 96-hour rainfall amounts of 9.61 and 8.70 inches, respectively. The majority of the rainfall occurred during a 52-hour period, beginning late at night on August 8. Within the South Skunk River Basin, peak discharges of 14,800 cubic feet per second (annual flood-probability estimate of 0.2 to 1 percent) at the 05470000 South Skunk River near Ames, Iowa streamgage; of 36,200 cubic feet per second (annual flood-probability estimate of less than 0.2 percent) at the 05471000 South Skunk River below Squaw Creek near Ames, Iowa streamgage (both on August 11, 2010); and of 24,000 cubic feet per second (annual flood-probability estimate of 0.2 to 1 percent) at 05471050 South Skunk River at Colfax, Iowa streamgage on August 14 are the largest floods on record for these sites. Peak discharges at 05470500 Squaw Creek at Ames, Iowa streamgage of 22,400 cubic feet per second (annual flood-probability estimate of less than 0.2 percent) on August 11; and at 05471500 South Skunk River near Oskaloosa, Iowa streamgage, of 25,200 cubic feet per second (annual flood- probability estimate of 1 to 2 percent) on August 16 are the second highest floods on record. This report provides a description of the watershed, the thunderstorms, the flooding, and a profile of high-water marks measured at 20 locations along the South Skunk River between County Road V67/280th Avenue, northeast of Ollie in Keokuk County and West Riverside Road in Ames, a distance of 128 river miles.