The Alaska Volcano Observatory (AVO) responded to eruptions, possible eruptions, volcanic unrest, or suspected unrest at 11 volcanic centers in Alaska during 2012. Of the two verified eruptions, one (Cleveland) was clearly magmatic and the other (Kanaga) was most likely a single phreatic explosion. Two other volcanoes had notable seismic swarms that probably were caused by magmatic intrusions (Iliamna and Little Sitkin). For each period of clear volcanic unrest, AVO staff increased monitoring vigilance as needed, reviewed eruptive histories of the volcanoes in question to help evaluate likely outcomes, and shared observations and interpretations with the public. 2012 also was the 100th anniversary of Alaska’s Katmai-Novarupta eruption of 1912, the largest eruption on Earth in the 20th century and one of the most important volcanic eruptions in modern times. AVO marked this occasion with several public events.