Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs

Journal of Wildlife Diseases
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Abstract

Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested as a potential biomarker for oral plague vaccination because it allows nonlethal sampling of animals through hair, blood, and feces. We found that RB is an appropriate marker for bait uptake studies of C. ludovicianus) when used at concentrations <0.5% of bait mass dosed to deliver >10 mg RB per kg target animal mass. Whiskers with follicles provided the best sample for RB detection.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs
Series title Journal of Wildlife Diseases
DOI 10.7589/0090-3558-47.3.765
Volume 47
Issue 3
Year Published 2011
Language English
Publisher Wildlife Disease Association
Publisher location Lawrence, KS
Contributing office(s) National Wildlife Health Center
Description 4 p.
First page 765
Last page 768
Online Only (Y/N) N
Additional Online Files (Y/N) N
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